• 
  Control-Tilde (~): Cycles through open application windows. This is a common macOS shortcut.
• 
  Control-Tab: Cycles focus between the sidebar, item list, view/edit pane, the Tags bar, and inspectors, depending on what elements are visible.
• 
  Escape: Cancels processes, closes dialogs or Quick Look previews, etc., depending on the context.
• 
  Command-}: Cycles to the next tab.
• 
  Command-{: Cycles to the previous tab.

Navigating items:

• 
  Up/Down arrow: Navigates up and down in all views. Use ⇧ to select multiple entries.
• 
  Left/Right arrow: Expands or collapses the selected groups in horizontal split, vertical split or List views, or navigates to previous/next item in other views.
• 
  Option-click (the triangle in front of a group): Expands or collapses all groups that are contained within this group as well.
• 
  Option-Left/Right arrow: Expands or collapses the selected groups and all their children the item list.

Selecting items:

• 
  Shift-click: Selects consecutive items.
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  Shift-arrow: Extends the next consecutive item to the current selection.
• 
  Command-click: Adds a non-consecutive item to the selection.

Manipulating items:

• 
  Return: Renames documents.
• 
  Backspace: Deletes selected items.
• 
  Command-Drag: When dragging items from the Finder, this moves, not copies, the file into the database.
• 
  Option-drag: Duplicates items to the drag destination instead of moving it.
• 
  Command-Option-drag: Creates replicants for the items at the drag destination. Dragging items from the Finder to DEVONthink with ⌥⌘ pressed indexes the item. Dragging items into documents with ⌥⌘ held inserts a link to the item.

Item List:

• 
  Command-Shift-O: Opens a selected document in the system default application.
• 
  Tab: Jumps to the first or next editable column when using the item list in List view.
• 
  Space: Opens the standard Quick Look panel showing a preview of the selected items.
• 
  Option-Space: Opens a full screen Quick Look slideshow.
• 
  Command-bracket: Using [ and ], goes backwards and forwards through the visited locations.

• 
  Home/End: Goes to beginning or end of any view.
• 
  Page up/down: Scrolls one page up and down in any view.
• 
  Space/Shift-Space: Scrolls one page down or up in non-editable views, e.g., web pages, images, or PDF documents.
• 
  Command-click: Opens the target of a link in a new tab or separate window.
• 
  Command-Shift-click: Opens a link in a new tab and activates it. This requires enabling tabbed browsing in Settings > General.
• 
  Option-click (a link): For HTML-based files, adds the clicked URL to the Download Manager panel.
• 
  Option-click (a word): Initiates a search with the clicked word as the search term.
• 
  Option-drag: Selects text using a rectangular selection ribbon.
• 
  Command-Option-drag: Inserts a cross-link for groups or documents dropped into a rich text document. Dragging files or folders from the Finder to a rich text document with ⌥⌘ pressed creates links to them.

PDFs and Images:

• 
  Control-Shift-Command- +: Zooms in.
• 
  Control-Shift-Command- —: Zooms out.
• 
  Command-0: Display at actual size.
• 
  Command-=: Zoom to fit.
• 
  Control-Command-W: Zoom to width.
• 
  Command-drag: Scrolls the visible area with the mouse.

Sheets:

• 
  Return: Moves one cell down for editing.
• 
  Shift-Return: Moves one cell up for editing.
• 
  Tab: Moves one cell to the right for editing.
• 
  Shift-Tab: Moves one cell to the left for editing.
• 
  Arrows: Moves the editing selection.
• 
  Escape: Stops editing.

Multimedia:

• 
  Spacebar: Start and stop playback.
• 
  Left/Right Arrows: Move forward or backward one frame or .25 second.
• 
  Option-Left/Right Arrows: Jump to the beginning or end of the file.
• 
  Shift-Left/Right Arrows: Move forward or backward in 15 second intervals. The Shift-interval is customizable in the hidden preferences.
• 
  Command-Left/Right Arrows: Change forward or reverse playback speeds.
• 
  Option-Forward/Reverse buttons: Hold the Option key and click the forward or reverse buttons to change playback speeds in .1 increments, e.g., 2.1, 2.2, etc.
• 
  Up/Down Arrows: Adjust the playback volume. Hold Option to switch between mute and full volume.

General Note Creation and Clipping:

• 
  Command-S: Saves the entered data. Equivalent to clicking Add.
• 
  Escape: Clears any entered data. Equivalent to pressing the retreating circle icon.

Voice and Video Note:

• 
  Spacebar: Start and stop recording.

Screen Capture:

• 
  Command-1: Capture the entire window.
• 
  Command-2: Capture a highlighted window.
• 
  Command-3: Capture a selected area.

Web Clip:

• 
  Command-1: Clips from the default browser.
• 
  Command-2: Clips from a URL you've copied to the clipboard.
• 
  Command-3: Type a URL to clip and any associated data, e.g., comments, tags, etc..

Clip to DEVONthink:

• 
  Command-F: Toggles the Clutter-free option.
• 
  Command 1-9: Chooses the format to clip to (in order from 1): Plain Text, Rich Text, Bookmark, Formatted Note, HTML Page, Markdown, Web Archive, PDF (One Page), and PDF (Paginated).